Predicting Pathologic Stage

Partin Coefficient Table I: PSA = 0.0 – 4.0 ng/ml

This table shows the probability of having each of the four pathologic stages of prostate cancer based on Gleason score, clinical stage and a PSA level between 0.0 and 4.0 ng/ml.

Examples

• A man with a PSA level of 3.2 ng/ml, a Gleason score of 3 and a clinical stage of T1b has an 80% chance of having organ-confined disease.
  
  
• A man with a PSA level of 2.7 ng/ml, a Gleason score of 6 and a clinical stage of T2c has a 4% chance of seminal vesicle involvement.

PSA = 0.0 – 4.0 ng/ml

Probability of Pathologic Stage (%)

		Clinical Stage
Gleason score	Pathologic stage	T1a	T1b	T1c	T2a	T2b	T2c	T3a
2-4	Organ-confined disease Established capsular penetration Seminal vesicle involvement Lymph node involvement	90 9 0 0	80 19 1 0	89 10 1 0	81 18 1 0	72 25 2 0	77 21 2 0	… … … …
5	Organ-confined disease Established capsular penetration Seminal vesicle involvement Lymph node involvement	82 17 1 0	66 32 2 1	81 18 1 0	68 30 2 0	57 40 3 1	62 34 3 1	40 51 7 2
6	Organ-confined disease Established capsular penetration Seminal vesicle involvement Lymph node involvement	78 19 1 1	61 35 2 2	78 21 1 0	64 34 2 1	52 43 3 2	57 37 4 2	35 53 7 5
7	Organ-confined disease Established capsular penetration Seminal vesicle involvement Lymph node involvement	… … … …	43 44 6 6	63 31 4 1	47 45 6 2	34 51 10 5	38 45 12 5	19 52 19 9
8-10	Organ-confined disease Established capsular penetration Seminal vesicle involvement Lymph node involvement	… … … …	31 43 11 14	52 34 9 4	36 47 12 5	24 48 17 10	27 42 21 10	… … … …

… lack of sufficient data to calculate probability

Reference: Partin AW, Kattan MW, Subong EN, Walsh PC, et al. Combination of prostate-specific antigen, clinical stage and Gleason score to predict pathological stage of localized prostate cancer: A multi-institutional update. JAMA 1997;277:1445-1451. Copyrighted 1997, American Medical Association. Reprinted with permission.