Predicting Pathologic Stage

Partin Coefficient Table: PSA > 20.0 ng/ml

This table shows the probability of having each of the four pathologic stages of prostate cancer based on Gleason score, clinical stage and a PSA level greater than 20.0 ng/ml.

Examples

• A man with a PSA level of 28.5 ng/ml, a Gleason score of 3 and a clinical stage of T1c has a 58% chance of having organ-confined disease.
  
  
• A man with a PSA level of 40.7 ng/ml, a Gleason score of 7 and a clinical stage of T2c has a 32% chance of seminal vesicle involvement.

PSA > 20.0 ng/ml

Probability of Pathologic Stage (%)

		Clinical Stage
Gleason score	Pathologic stage	T1a	T1b	T1c	T2a	T2b	T2c	T3a
2-4	Organ-confined disease Established capsular penetration Seminal vesicle involvement Lymph node involvement	… … … …	38 47 9 4	58 34 7 1	41 48 10 1	29 52 14 3	… … … …	… … … …
5	Organ-confined disease Established capsular penetration Seminal vesicle involvement Lymph node involvement	… … … …	23 57 10 10	40 48 9 3	26 60 11 3	17 61 15 7	19 55 19 7	8 54 26 11
6	Organ-confined disease Established capsular penetration Seminal vesicle involvement Lymph node involvement	… … … …	17 51 8 23	35 49 8 7	22 60 10 8	13 57 13 16	15 51 17 17	6 46 21 26
7	Organ-confined disease Established capsular penetration Seminal vesicle involvement Lymph node involvement	… … … …	… … … …	18 46 22 14	10 51 24 14	5 43 27 25	6 37 32 25	2 29 36 32
8-10	Organ-confined disease Established capsular penetration Seminal vesicle involvement Lymph node involvement	… … … …	3 24 20 51	10 34 31 24	5 37 33 24	3 28 33 36	3 23 38 35	1 17 40 42

… lack of sufficient data to calculate probability

Reference: Partin AW, Kattan MW, Subong EN, Walsh PC, et al. Combination of prostate-specific antigen, clinical stage and Gleason score to predict pathological stage of localized prostate cancer: A multi-institutional update. JAMA 1997;277:1445-1451. Copyrighted 1997, American Medical Association. Reprinted with permission.