UPMC Cancer Centers works in tandem with the University of Pittsburgh Cancer Institute (UPCI), which comprises the academic and research activities for cancer at the University of Pittsburgh and UPMC, to offer patients the latest advances in cancer prevention, detection, diagnosis and treatment. A variety of clinical and laboratory investigations are underway under the direction of stem cell transplantation researchers at UPCI’s Hematologic Malignancies Program. A number of ongoing clinical trials in stem cell transplantation are underway to test promising new therapies.
The Stem Cell Transplantation Program is actively involved in clinical research to improve stem cell transplantation. These include:
Through the Stem Cell Transplantation Program, Program scientists are conducting studies on the basic biology of stem cells and the immune system to enhance transplant success and to expand the application of transplants to different diseases. Current projects in the area of immunobiology, immunotherapy and hematopoietic stem cell transplant include: a) delineation of the inflammatory signaling pathways during the early phase of Graft-versus-Host disease (GVHD) with the aim of developing targeted approaches that can reduce the transplantation-induced inflammatory reaction and thereby prevent the development of graft vs host disease (GVHD) b) mechanism(s) by which donor lymphocyte infusions induce Graft-versus-Leukemia (GVL), and development of strategies to enhance GVL effect; c) identification of minor histocompatibility antigens in order to achieve a more selective targeting of host hematopoietic cells by GVL effect.
For more detailed information on the Program’s research activities, including current research, accomplishments and future directions, visit the Hematologic Malignancies Program at the University of Pittsburgh Cancer Institute.
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